8z0n: Difference between revisions

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'''Unreleased structure'''


The entry 8z0n is ON HOLD
==Structure and dynamics of Drk-SH2 domain and its site-specific interaction with Sev==
<StructureSection load='8z0n' size='340' side='right'caption='[[8z0n]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8z0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z0N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z0n OCA], [https://pdbe.org/8z0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z0n RCSB], [https://www.ebi.ac.uk/pdbsum/8z0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z0n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GRAP_DROME GRAP_DROME] Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as sev and Ack (PubMed:22615583, PubMed:8462097, PubMed:8462098). Required for proper signaling by sevenless (PubMed:8462097, PubMed:8462098). May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex (PubMed:8462097, PubMed:8462098). Required for functional and morphological integrities of the scolopidia, sensory neurons and the antennal mechanosensory and motor center (AMMC) brain neuropil (PubMed:30610177). Required for Ack-dependent suppression of apoptosis in the eye (PubMed:22615583).<ref>PMID:22615583</ref> <ref>PMID:30610177</ref> <ref>PMID:8462097</ref> <ref>PMID:8462098</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Drosophila downstream receptor kinase (Drk), a homologue of human GRB2, participates in the signal transduction from the extracellular to the intracellular environment. Drk receives signals through the interaction of its Src homology 2 (SH2) domain with the phosphorylated tyrosine residue in the receptor tyrosine kinases (RTKs). Here, we present the solution NMR structure of the SH2 domain of Drk (Drk-SH2), which was determined in the presence of a phosphotyrosine (pY)-containing peptide derived from a receptor tyrosine kinase, Sevenless (Sev). The solution structure of Drk-SH2 possess a common SH2 domain architecture, consisting of three beta strands imposed between two alpha helices. Additionally, we interpret the site-specific interactions of the Drk-SH2 domain with the pY-containing peptide through NMR titration experiments. The dynamics of Drk-SH2 were also analysed through NMR-relaxation experiments as well as the molecular dynamic simulation. The docking simulations of the pY-containing peptide onto the protein surface of Drk-SH2 provided the orientation of the peptide, which showed a good agreement with the analysis of the SH2 domain of GRB2.


Authors: Sayeesh, P.M., Mayumi, I., Inomata, K., IKeya, T., Ito, Y.
Structure and Dynamics of Drk-SH2 Domain and Its Site-Specific Interaction with Sev Receptor Tyrosine Kinase.,Sayeesh PM, Iguchi M, Inomata K, Ikeya T, Ito Y Int J Mol Sci. 2024 Jun 9;25(12):6386. doi: 10.3390/ijms25126386. PMID:38928093<ref>PMID:38928093</ref>


Description: Structure and dynamics of Drk-SH2 domain and its site-specific interaction with Sev
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Inomata, K]]
<div class="pdbe-citations 8z0n" style="background-color:#fffaf0;"></div>
[[Category: Mayumi, I]]
== References ==
[[Category: Sayeesh, P.M]]
<references/>
[[Category: Ito, Y]]
__TOC__
[[Category: Ikeya, T]]
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: IKeya T]]
[[Category: Inomata K]]
[[Category: Ito Y]]
[[Category: Mayumi I]]
[[Category: Sayeesh PM]]
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