9exj: Difference between revisions
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New page: '''Unreleased structure''' The entry 9exj is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Crystal structure of Aspergillus fumigatus AA11 Lytic Polysaccharide Monooxygenase (AfAA11B) in complex with Cu(II)== | |||
<StructureSection load='9exj' size='340' side='right'caption='[[9exj]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9exj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus_Af293 Aspergillus fumigatus Af293]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EXJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9exj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9exj OCA], [https://pdbe.org/9exj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9exj RCSB], [https://www.ebi.ac.uk/pdbsum/9exj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9exj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LP11B_ASPFU LP11B_ASPFU] Lytic polysaccharide monooxygenase (LPMO)-like protein that acts as a strict peroxygenase and does not catalyze a monooxygenase reaction (PubMed:34567832). It is indeed hardly active on chitin, while being very active on soluble oligomers of N-acetylglucosamine (PubMed:34567832). Cleaves the glycosidic bonds byoxidizing the C1 position (PubMed:34567832). Also unable to oxidize cellopentaose (PubMed:34738811). Probably breaks glycosidic bonds in non-polymeric substrates possibly carbohydrates in the cell wall of the fungus or its competitors (PubMed:34567832). In the presence of chitotetraose, the enzyme can withstand considerable amounts of H(2)O(2), which it uses to efficiently and stoichiometrically convert this substrate (PubMed:34567832).<ref>PMID:34567832</ref> <ref>PMID:34738811</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Aspergillus fumigatus Af293]] | |||
[[Category: Large Structures]] | |||
[[Category: Ayuso-Fernandez I]] | |||
[[Category: Dalleywater EL]] | |||
[[Category: Englund ANB]] | |||
[[Category: Golten O]] | |||
[[Category: Hall KR]] | |||
[[Category: Rieder L]] | |||
[[Category: Rohr AK]] | |||
[[Category: Ronnekleiv SE]] | |||
[[Category: Skaali R]] | |||
[[Category: Sorlie M]] | |||
Latest revision as of 05:25, 23 April 2025
Crystal structure of Aspergillus fumigatus AA11 Lytic Polysaccharide Monooxygenase (AfAA11B) in complex with Cu(II)
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