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[[Image:1rnd.gif|left|200px]]
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{{STRUCTURE_1rnd|  PDB=1rnd  |  SCENE=  }}
'''NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE'''


==NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE==
<StructureSection load='1rnd' size='340' side='right'caption='[[1rnd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1rnd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RND FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGP:2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>DGP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rnd OCA], [https://pdbe.org/1rnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rnd RCSB], [https://www.ebi.ac.uk/pdbsum/1rnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rnd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/1rnd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rnd ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a reexamination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the complex that involved a guanine mononucleotide.


==Overview==
Newly observed binding mode in pancreatic ribonuclease.,Aguilar CF, Thomas PJ, Mills A, Moss DS, Palmer RA J Mol Biol. 1992 Mar 5;224(1):265-7. PMID:1548704<ref>PMID:1548704</ref>
Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a reexamination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the complex that involved a guanine mononucleotide.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1RND is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RND OCA].
</div>
<div class="pdbe-citations 1rnd" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Newly observed binding mode in pancreatic ribonuclease., Aguilar CF, Thomas PJ, Mills A, Moss DS, Palmer RA, J Mol Biol. 1992 Mar 5;224(1):265-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1548704 1548704]
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Pancreatic ribonuclease]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Aguilar CF]]
[[Category: Aguilar, C F.]]
[[Category: Mills A]]
[[Category: Mills, A.]]
[[Category: Moss DS]]
[[Category: Moss, D S.]]
[[Category: Palmer RA]]
[[Category: Palmer, R A.]]
[[Category: Thomas PJ]]
[[Category: Thomas, P J.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:41:49 2008''

Latest revision as of 04:51, 17 October 2024

NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE

1rnd, resolution 1.50Å

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