1u9e: Difference between revisions
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New page: left|200px<br /> <applet load="1u9e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u9e, resolution 2.40Å" /> '''CRYSTAL STRUCTURE O... |
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== | ==CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-397== | ||
<StructureSection load='1u9e' size='340' side='right'caption='[[1u9e]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1u9e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U9E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=397:2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL'>397</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9e OCA], [https://pdbe.org/1u9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u9e RCSB], [https://www.ebi.ac.uk/pdbsum/1u9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u9/1u9e_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u9e ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Akopian | [[Category: Akopian T]] | ||
[[Category: Alvarez | [[Category: Alvarez JC]] | ||
[[Category: Bapat | [[Category: Bapat A]] | ||
[[Category: Bhat | [[Category: Bhat RA]] | ||
[[Category: Harris | [[Category: Harris HA]] | ||
[[Category: Hsiao | [[Category: Hsiao C]] | ||
[[Category: Hum | [[Category: Hum WT]] | ||
[[Category: Malakian | [[Category: Malakian K]] | ||
[[Category: Malamas | [[Category: Malamas MS]] | ||
[[Category: Manas | [[Category: Manas ES]] | ||
[[Category: Miller | [[Category: Miller CP]] | ||
[[Category: Somers | [[Category: Somers WS]] | ||
[[Category: Stahl | [[Category: Stahl ML]] | ||
[[Category: Unwalla | [[Category: Unwalla RJ]] | ||
[[Category: Wolfrom | [[Category: Wolfrom S]] | ||
[[Category: Xu | [[Category: Xu ZB]] | ||
Latest revision as of 08:44, 14 February 2024
CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-397
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