8z3o: Difference between revisions
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==Cryo-EM structure of the receptor of hGPR68-Gs complex in pH6.0== | |||
<StructureSection load='8z3o' size='340' side='right'caption='[[8z3o]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8z3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z3O FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z3o OCA], [https://pdbe.org/8z3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z3o RCSB], [https://www.ebi.ac.uk/pdbsum/8z3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z3o ProSAT]</span></td></tr> | ||
[[Category: Guo | </table> | ||
[[Category: Zhong | == Disease == | ||
[https://www.uniprot.org/uniprot/OGR1_HUMAN OGR1_HUMAN] Hypomaturation amelogenesis imperfecta. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/OGR1_HUMAN OGR1_HUMAN] Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity).<ref>PMID:12955148</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Guo LL]] | |||
[[Category: Zhong YN]] | |||
Latest revision as of 05:15, 23 April 2025
Cryo-EM structure of the receptor of hGPR68-Gs complex in pH6.0
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