8z67: Difference between revisions

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New page: '''Unreleased structure''' The entry 8z67 is ON HOLD Authors: Zhong, Y.N., Guo, L.L., Yang, F., Sun, J.P. Description: Cryo-EM structure of the hGPR68-Gs complex in pH6.8 [[Category: U...
 
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'''Unreleased structure'''


The entry 8z67 is ON HOLD
==Cryo-EM structure of the hGPR68-Gs complex in pH6.8==
 
<StructureSection load='8z67' size='340' side='right'caption='[[8z67]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
Authors: Zhong, Y.N., Guo, L.L., Yang, F., Sun, J.P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8z67]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z67 FirstGlance]. <br>
Description: Cryo-EM structure of the hGPR68-Gs complex in pH6.8
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z67 OCA], [https://pdbe.org/8z67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z67 RCSB], [https://www.ebi.ac.uk/pdbsum/8z67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z67 ProSAT]</span></td></tr>
[[Category: Sun, J.P]]
</table>
[[Category: Guo, L.L]]
== Function ==
[[Category: Yang, F]]
[https://www.uniprot.org/uniprot/GPR4_HUMAN GPR4_HUMAN] Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways (PubMed:12955148, PubMed:17462861, PubMed:20211729, PubMed:22110680). Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway (PubMed:32058960). In the brain may mediate central respiratory sensitivity to CO(2)H(+) (By similarity).[UniProtKB:Q8BUD0]<ref>PMID:12955148</ref> <ref>PMID:17462861</ref> <ref>PMID:20211729</ref> <ref>PMID:22110680</ref> <ref>PMID:32058960</ref>
[[Category: Zhong, Y.N]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Guo LL]]
[[Category: Sun JP]]
[[Category: Yang F]]
[[Category: Zhong YN]]
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