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[[Image:1rzi.gif|left|200px]]
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{{STRUCTURE_1rzi|  PDB=1rzi  |  SCENE=  }}
'''Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab'''


==Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab==
<StructureSection load='1rzi' size='340' side='right'caption='[[1rzi]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1rzi]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzi OCA], [https://pdbe.org/1rzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rzi RCSB], [https://www.ebi.ac.uk/pdbsum/1rzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rzi ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rzi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rzi ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.


==Overview==
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.,Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267<ref>PMID:14981267</ref>
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZI OCA].
</div>
<div class="pdbe-citations 1rzi" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14981267 14981267]
*[[Antibody 3D structures|Antibody 3D structures]]
[[Category: Choe, H.]]
*[[Sandbox 20009|Sandbox 20009]]
[[Category: Dimitrov, D S.]]
*[[3D structures of human antibody|3D structures of human antibody]]
[[Category: Farzan, M.]]
== References ==
[[Category: Hendrickson, W A.]]
<references/>
[[Category: Huang, C C.]]
__TOC__
[[Category: Kwong, P D.]]
</StructureSection>
[[Category: Majeed, S.]]
[[Category: Homo sapiens]]
[[Category: Moore, M J.]]
[[Category: Large Structures]]
[[Category: Phogat, S.]]
[[Category: Choe H]]
[[Category: Robinson, J.]]
[[Category: Dimitrov DS]]
[[Category: Sodroski, J.]]
[[Category: Farzan M]]
[[Category: Venturi, M.]]
[[Category: Hendrickson WA]]
[[Category: Wyatt, R.]]
[[Category: Huang CC]]
[[Category: Zhang, M Y.]]
[[Category: Kwong PD]]
[[Category: Antibody]]
[[Category: Majeed S]]
[[Category: Cd4i]]
[[Category: Moore MJ]]
[[Category: Gp120]]
[[Category: Phogat S]]
[[Category: Hiv-1]]
[[Category: Robinson J]]
[[Category: Tyrosine sulfation]]
[[Category: Sodroski J]]
[[Category: Vh-gene usage]]
[[Category: Venturi M]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:06:14 2008''
[[Category: Wyatt R]]
[[Category: Zhang M-Y]]

Latest revision as of 07:26, 9 October 2024

Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab

1rzi, resolution 2.90Å

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