9bqd: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 9bqd is ON HOLD Authors: Description: Category: Unreleased Structures |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Human Topoisomerase 2 Beta ATPase domain bound to topobexin and non-hydrolyzable ATP analog AMPPNP== | |||
<StructureSection load='9bqd' size='340' side='right'caption='[[9bqd]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9bqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BQD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ASC:8-(3,4-dihydroquinoline-1(2H)-carbonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-4-propyl-2H-1-benzopyran-2-one'>A1ASC</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bqd OCA], [https://pdbe.org/9bqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bqd RCSB], [https://www.ebi.ac.uk/pdbsum/9bqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bqd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Alvey JA]] | |||
[[Category: Applova L]] | |||
[[Category: Arrouye L]] | |||
[[Category: Austin CA]] | |||
[[Category: Cong ATQ]] | |||
[[Category: Jirkovska A]] | |||
[[Category: Karabanovich G]] | |||
[[Category: Kerestes V]] | |||
[[Category: Kollarova P]] | |||
[[Category: Kubes J]] | |||
[[Category: Kunes J]] | |||
[[Category: Lencova O]] | |||
[[Category: Melnikova I]] | |||
[[Category: Paluncic J]] | |||
[[Category: Piskackova HB]] | |||
[[Category: Roh J]] | |||
[[Category: Schellenberg MJ]] | |||
[[Category: Simunek T]] | |||
[[Category: Sterba M]] | |||
[[Category: Sterbova P]] | |||
[[Category: Witter TL]] | |||
Latest revision as of 06:08, 25 June 2025
Human Topoisomerase 2 Beta ATPase domain bound to topobexin and non-hydrolyzable ATP analog AMPPNP
| ||||||||||||
