A Disintegrin And Metalloproteinase: Difference between revisions
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* '''ADAM17''' (TACE or TNF-α converting enzyme) processes the tumor necrosis factor-α.<br /> | * '''ADAM17''' (TACE or TNF-α converting enzyme) processes the tumor necrosis factor-α.<br /> | ||
* '''ADAM33''' is implicated in asthma.<br /> | * '''ADAM33''' is implicated in asthma.<br /> | ||
* '''ADAMTS''' is ADAM with thrombospondin motifs. <br /> | * '''ADAMTS''' is ADAM with thrombospondin motifs<ref>PMID:15554875</ref>. <br /> | ||
* '''ADAMTS1''' has anti-angionenic activity. <br /> | * '''ADAMTS1''' has anti-angionenic activity<ref>PMID:10811842</ref>. <br /> | ||
* '''ADAMTS4''' and '''ADAMTS5''' are involved in the degradation of aggrecan.<br /> | * '''ADAMTS4''' and '''ADAMTS5''' are involved in the degradation of aggrecan.<br /> | ||
* '''ADAMTS13''' cleaves [[Von Willebrand Factor]] involved in blood clotting | * '''ADAMTS13''' cleaves [[Von Willebrand Factor]] involved in blood clotting<ref>PMID:18762209</ref>. | ||
<ref>PMID:18762209</ref> | |||
== Disease == | == Disease == | ||
ADAM inhibitors are used in anti-cancer therapy. ADAM10 is a therapeutic target for cancer and inflammation <ref>PMID:19601831</ref>. ADAM17 is a therapeutic target for multiple diseases <ref>PMID:19601834</ref>.ADAM33 is implicated in asthma. | ADAM inhibitors are used in anti-cancer therapy. '''ADAM10''' is a therapeutic target for cancer and inflammation <ref>PMID:19601831</ref>. '''ADAM17''' is a therapeutic target for multiple diseases <ref>PMID:19601834</ref>. '''ADAM33''' is implicated in asthma. '''ADAM33''' is a therapeutic target for asthma <ref>PMID:38396994</ref>. '''ADAMTS4''' is involved in various CNS pathologies<ref>PMID:28084617</ref>. | ||
== 3D Structures of A Disintegrin And Metalloproteinase == | == 3D Structures of A Disintegrin And Metalloproteinase == | ||
