1s7o: Difference between revisions

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[[Image:1s7o.gif|left|200px]]


<!--
==Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes==
The line below this paragraph, containing "STRUCTURE_1s7o", creates the "Structure Box" on the page.
<StructureSection load='1s7o' size='340' side='right'caption='[[1s7o]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1s7o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M3 Streptococcus pyogenes serotype M3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S7O FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7o OCA], [https://pdbe.org/1s7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s7o RCSB], [https://www.ebi.ac.uk/pdbsum/1s7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7o ProSAT], [https://www.topsan.org/Proteins/BSGC/1s7o TOPSAN]</span></td></tr>
{{STRUCTURE_1s7o|  PDB=1s7o  |  SCENE= }}
</table>
 
== Function ==
'''Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes'''
[https://www.uniprot.org/uniprot/Y842_STRP3 Y842_STRP3] Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein (By similarity).
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
The crystal structure of the putative DNA-binding protein SP_1288 (gi/15675166, also listed as gi/28895954) from Streptococcus pyogenes has been determined by X-ray crystallography to a resolution of 2.3 A using anomalous diffraction data at the Se peak wavelength. SP_1288 belongs to a family of proteins whose cellular function is associated with the signal recognition particle; no structural information has been available until now about the members of the family. Crystallographic analysis revealed that the overall fold of SP_1288 consists exclusively of alpha-helices and that 75% of the structure has good similarity to domain 4 of the sigma subunit of RNA polymerase. This suggests its possible involvement in the biochemical function of transcription initiation, which includes interaction with DNA.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s7/1s7o_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
1S7O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7O OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s7o ConSurf].
Structure of the putative DNA-binding protein SP_1288 from Streptococcus pyogenes., Oganesyan V, Pufan R, DeGiovanni A, Yokota H, Kim R, Kim SH, Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1266-71. Epub 2004, Jun 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15213388 15213388]
<div style="clear:both"></div>
[[Category: Single protein]]
__TOC__
[[Category: Streptococcus pyogenes]]
</StructureSection>
[[Category: BSGC, Berkeley Structural Genomics Center.]]
[[Category: Large Structures]]
[[Category: DeGiovanni, A.]]
[[Category: Streptococcus pyogenes serotype M3]]
[[Category: Kim, R.]]
[[Category: DeGiovanni A]]
[[Category: Kim, S H.]]
[[Category: Kim R]]
[[Category: Oganesyan, V.]]
[[Category: Kim S-H]]
[[Category: Pufan, R.]]
[[Category: Oganesyan V]]
[[Category: Yokota, H.]]
[[Category: Pufan R]]
[[Category: Berkeley structural genomics center]]
[[Category: Yokota H]]
[[Category: Bsgc]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Putative dna binding protein]]
[[Category: Rna polymerase sigma factor]]
[[Category: Signal recognition particle]]
[[Category: Structural genomic]]
[[Category: Structure funded by nih]]
[[Category: Upf0122]]
[[Category: X-rat crystallography]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:24:00 2008''

Latest revision as of 08:28, 14 February 2024

Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes

1s7o, resolution 2.31Å

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