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[[Image:1sbs.gif|left|200px]]
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{{STRUCTURE_1sbs|  PDB=1sbs  |  SCENE=  }}
'''CRYSTAL STRUCTURE OF AN ANTI-HCG FAB'''


==CRYSTAL STRUCTURE OF AN ANTI-HCG FAB==
<StructureSection load='1sbs' size='340' side='right'caption='[[1sbs]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1sbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SBS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sbs OCA], [https://pdbe.org/1sbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sbs RCSB], [https://www.ebi.ac.uk/pdbsum/1sbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sbs ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sb/1sbs_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sbs ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
3A2 is an antibody raised against human chorionic gonadotropin and recognizes a linear epitope on the C-terminal peptide of the human chorionic gonadotropin beta-subunit. Its three-dimensional structure has been determined to 2-A resolution using molecular replacement and refined to a conventional R-factor of 18.2%. The protein exhibits the typical immunoglobulin fold, and the model contains 944 ordered water molecules and one sulfate ion. A comparison of the complementarity-determining regions of the Fab3A2 with those from the Protein Data Bank following the canonical structure method reveals a canonical main chain conformation. This antibody belongs to the canonical structure class (combination of canonical conformations of the complementarity determining loops) that shows a preference for haptens and not for peptides. However, the shape of the surface of the antigen binding loops resembles that of an anti-peptide antibody.


==Overview==
Structure of an Fab fragment against a C-terminal peptide of hCG at 2.0 A resolution.,Fotinou C, Beauchamp J, Emsley P, deHaan A, Schielen WJ, Bos E, Isaacs NW J Biol Chem. 1998 Aug 28;273(35):22515-8. PMID:9712877<ref>PMID:9712877</ref>
3A2 is an antibody raised against human chorionic gonadotropin and recognizes a linear epitope on the C-terminal peptide of the human chorionic gonadotropin beta-subunit. Its three-dimensional structure has been determined to 2-A resolution using molecular replacement and refined to a conventional R-factor of 18.2%. The protein exhibits the typical immunoglobulin fold, and the model contains 944 ordered water molecules and one sulfate ion. A comparison of the complementarity-determining regions of the Fab3A2 with those from the Protein Data Bank following the canonical structure method reveals a canonical main chain conformation. This antibody belongs to the canonical structure class (combination of canonical conformations of the complementarity determining loops) that shows a preference for haptens and not for peptides. However, the shape of the surface of the antigen binding loops resembles that of an anti-peptide antibody.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1SBS is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBS OCA].
</div>
<div class="pdbe-citations 1sbs" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Structure of an Fab fragment against a C-terminal peptide of hCG at 2.0 A resolution., Fotinou C, Beauchamp J, Emsley P, deHaan A, Schielen WJ, Bos E, Isaacs NW, J Biol Chem. 1998 Aug 28;273(35):22515-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9712877 9712877]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Beauchamp J]]
[[Category: Beauchamp, J.]]
[[Category: Bos E]]
[[Category: Bos, E.]]
[[Category: Dehaan A]]
[[Category: Dehaan, A.]]
[[Category: Emsley P]]
[[Category: Emsley, P.]]
[[Category: Fotinou C]]
[[Category: Fotinou, C.]]
[[Category: Isaacs NW]]
[[Category: Isaacs, N W.]]
[[Category: Schielen WJG]]
[[Category: Schielen, W J.G.]]
[[Category: Fab-fragment]]
[[Category: Monoclonal antibody]]
[[Category: Reproduction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:31:23 2008''

Latest revision as of 07:23, 30 October 2024

CRYSTAL STRUCTURE OF AN ANTI-HCG FAB

1sbs, resolution 2.00Å

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