8s7i: Difference between revisions

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'''Unreleased structure'''


The entry 8s7i is ON HOLD  until Paper Publication
==Fructose 6-phosphate aldolase, L107C/A129G/R134V/L163C/S166G mutant==
 
<StructureSection load='8s7i' size='340' side='right'caption='[[8s7i]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
Authors: Hebert, H., Widersten, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8s7i]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21 Escherichia coli BL21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8S7I FirstGlance]. <br>
Description: Fructose 6-phosphate aldolase, L107C/A129G/R134V/L163C/S166G mutant
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1H5N:(2~{S})-2-azanyl-6-[(~{E})-(2-oxidanyl-1-phenyl-ethylidene)amino]hexanoic+acid'>A1H5N</scene></td></tr>
[[Category: Widersten, M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8s7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s7i OCA], [https://pdbe.org/8s7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s7i RCSB], [https://www.ebi.ac.uk/pdbsum/8s7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s7i ProSAT]</span></td></tr>
[[Category: Hebert, H]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli BL21]]
[[Category: Large Structures]]
[[Category: Hebert H]]
[[Category: Widersten M]]
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