8tf1: Difference between revisions
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==Crystal Structure of Pyridoxal Reductase (PDXI)in complex with NADPH and Pyridoxal== | |||
<StructureSection load='8tf1' size='340' side='right'caption='[[8tf1]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8tf1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TF1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=UEG:4,5-BIS(HYDROXYMETHYL)-2-METHYL-PYRIDIN-3-OL'>UEG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tf1 OCA], [https://pdbe.org/8tf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tf1 RCSB], [https://www.ebi.ac.uk/pdbsum/8tf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tf1 ProSAT]</span></td></tr> | ||
[[Category: Musayev | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/PDXI_ECOLI PDXI_ECOLI] Catalyzes the NAD(P)H-dependent reduction of pyridoxal to pyridoxine in vitro. Is not able to reduce 4-pyridoxate, and to oxidize pyridoxine or pyridoxamine (PubMed:27941785). Has Kemp eliminase activity towards the non-physiological substrate 5-nitrobenzisoxazole, producing 4-nitro-2-cyanophenol; this activity is not considered to be physiologically relevant (PubMed:21332126).<ref>PMID:21332126</ref> <ref>PMID:27941785</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | |||
[[Category: Large Structures]] | |||
[[Category: Donkor AK]] | |||
[[Category: Musayev FN]] | |||
[[Category: Safo MK]] | |||
Latest revision as of 06:25, 18 December 2024
Crystal Structure of Pyridoxal Reductase (PDXI)in complex with NADPH and Pyridoxal
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