9f6p: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9f6p is ~~ON HOLD until Paper Publication~~

==Human NRAMP1 (SLC11A1) in complex with manganese, towards the inward-open state==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9f6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9F6P OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9F6P FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9f6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9f6p OCA], [https://pdbe.org/9f6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9f6p RCSB], [https://www.ebi.ac.uk/pdbsum/9f6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9f6p ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/NRAM1_HUMAN NRAM1_HUMAN] Cystic fibrosis;Tuberculosis.

== Function ==

[https://www.uniprot.org/uniprot/NRAM1_HUMAN NRAM1_HUMAN] Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity (PubMed:11237855). Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (Probable).<ref>PMID:11237855</ref> <ref>PMID:16103355</ref> <ref>PMID:16395392</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Dutzler R]]

[[Category: Liziczai M]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9f6p is ON HOLD  until Paper Publication
+==Human NRAMP1 (SLC11A1) in complex with manganese, towards the inward-open state==
+<StructureSection load='9f6p' size='340' side='right'caption='[[9f6p]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9f6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9F6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9F6P FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9f6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9f6p OCA], [https://pdbe.org/9f6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9f6p RCSB], [https://www.ebi.ac.uk/pdbsum/9f6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9f6p ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/NRAM1_HUMAN NRAM1_HUMAN] Cystic fibrosis;Tuberculosis.
+== Function ==
+[https://www.uniprot.org/uniprot/NRAM1_HUMAN NRAM1_HUMAN] Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity (PubMed:11237855). Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (Probable).<ref>PMID:11237855</ref> <ref>PMID:16103355</ref> <ref>PMID:16395392</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Dutzler R]]
+[[Category: Liziczai M]]