Contactin: Difference between revisions
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'''Contactin''' (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems<ref>PMID:16029194</ref>. | '''Contactin''' (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems<ref>PMID:16029194</ref>. | ||
*'''Contactin-2''' is a synaptic membrane protein involved in pathology of Alzheimer Disease<ref>PMID:29859129</ref>. | *'''Contactin-2''' is a synaptic membrane protein involved in pathology of Alzheimer Disease<ref>PMID:29859129</ref>. | ||
*'''Contactin-4''' ,''' contactin-5''' and '''contactin-6''' are involved in brain developmen<ref>PMID:23519440</ref>. | |||
== Disease == | == Disease == | ||
contactin-4 | Mutations in contactin-4, contactin-5 and contactin-6 confer risk of autism <ref>PMID:21308999</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[3s97]] – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase ζ - human <br /> | **[[3s97]] – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase ζ - human <br /> | ||
**[[2ee2]] – hCNTN FN3 domains - NMR <br /> | **[[2ee2]] – hCNTN FN3 domains 798-903 - NMR <br /> | ||
**[[5e53]] – cCNTN FN1-FN3 domains – chicken <br /> | **[[7ol2]] – mCNTN Ig1-Ig6 domains 28-608 - mouse <br /> | ||
**[[5e53]] – cCNTN FN1-FN3 domains 601-893 – chicken <br /> | |||
* Contactin-2 | * Contactin-2 | ||
**[[2om5]] – hCNTN Ig1-Ig4 domains | **[[8k53]], [[9ba4]] – hCNTN – Cryo EM <br /> | ||
**[[5e7l]] – mCNTN FN1-FN3 domains – | **[[2om5]] – hCNTN Ig1-Ig4 domains 34-414 <br /> | ||
**[[8k3j]] – hCNTN Ig1-Ig6<br /> | |||
**[[9ba5]] – hCNTN Ig1-Ig6 – Cryo EM<br /> | |||
**[[5e7l]] – mCNTN FN1-FN3 domains 609-911 <br/ > | |||
**[[8a0y]] – mCNTN Ig1-Ig6 domains 28-608 <br /> | |||
**[[7ol4]] – mCNTN Ig1-Ig6 domains + neurofascin<br /> | |||
* Contactin-3 | * Contactin-3 | ||
