Cyclohydrolase: Difference between revisions
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== Function == | == Function == | ||
Cyclohydrolase is an enzyme which catalyzes the reversible cyclization or the ring opening of a purine ring. | '''Cyclohydrolase''' is an enzyme which catalyzes the reversible cyclization or the ring opening of a purine ring. | ||
• '''GTP cyclohydrolase I''' catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis<ref>PMID:7663943</ref> <br /> | • '''GTP cyclohydrolase I''' catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis<ref>PMID:7663943</ref> <br /> | ||
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• '''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis<ref>PMID:23013430</ref> <br /> | • '''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis<ref>PMID:23013430</ref> <br /> | ||
*'''Methylenetetrahydrofolate dehydrogenase/cyclohydrolase''' catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells.<ref>PMID:10828945</ref> | *'''Methylenetetrahydrofolate dehydrogenase/cyclohydrolase''' catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells.<ref>PMID:10828945</ref> | ||
*'''Phosphoribosyl AMP-cyclohydrolase''' catalyzes the third step of His biosynthesis.<ref>PMID:22741521</ref> | |||
== Disease == | == Disease == | ||
