8cpg: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Structure of the AT-Hook 1 peptide from the mammalian HMGA protein in complex with DNA== | |||
<StructureSection load='8cpg' size='340' side='right'caption='[[8cpg]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8cpg]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CPG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cpg OCA], [https://pdbe.org/8cpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cpg RCSB], [https://www.ebi.ac.uk/pdbsum/8cpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cpg ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Boer | == Disease == | ||
[https://www.uniprot.org/uniprot/HMGA1_HUMAN HMGA1_HUMAN] A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HMGA1_HUMAN HMGA1_HUMAN] HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Boer DR]] | |||
[[Category: Campos JL]] | |||
Latest revision as of 06:02, 11 September 2024
Structure of the AT-Hook 1 peptide from the mammalian HMGA protein in complex with DNA
| ||||||||||||
