9c7n: Difference between revisions

Latest revision as of 07:17, 8 October 2025

Crystal Structure of the GL3 ACT-like Domain

Structural highlights

9c7n is a 5 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.85Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GL3_ARATH Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Negatively regulates stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication. Also regulates trichome cell wall maturation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Also seems to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Activates the transcription of GL2.^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7]

References

↑ Payne CT, Zhang F, Lloyd AM. GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1. Genetics. 2000 Nov;156(3):1349-62. PMID:11063707 doi:10.1093/genetics/156.3.1349
↑ Zhang F, Gonzalez A, Zhao M, Payne CT, Lloyd A. A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis. Development. 2003 Oct;130(20):4859-69. Epub 2003 Aug 13. PMID:12917293 doi:https://dx.doi.org/10.1242/dev.00681
↑ Ramsay NA, Walker AR, Mooney M, Gray JC. Two basic-helix-loop-helix genes (MYC-146 and GL3) from Arabidopsis can activate anthocyanin biosynthesis in a white-flowered Matthiola incana mutant. Plant Mol Biol. 2003 Jun;52(3):679-88. doi: 10.1023/a:1024852021124. PMID:12956536 doi:https://dx.doi.org/10.1023/a:1024852021124
↑ Esch JJ, Chen M, Sanders M, Hillestad M, Ndkium S, Idelkope B, Neizer J, Marks MD. A contradictory GLABRA3 allele helps define gene interactions controlling trichome development in Arabidopsis. Development. 2003 Dec;130(24):5885-94. PMID:14561633 doi:10.1242/dev.00812
↑ Bernhardt C, Lee MM, Gonzalez A, Zhang F, Lloyd A, Schiefelbein J. The bHLH genes GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) specify epidermal cell fate in the Arabidopsis root. Development. 2003 Dec;130(26):6431-9. Epub 2003 Nov 19. PMID:14627722 doi:https://dx.doi.org/10.1242/dev.00880
↑ Zimmermann IM, Heim MA, Weisshaar B, Uhrig JF. Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins. Plant J. 2004 Oct;40(1):22-34. doi: 10.1111/j.1365-313X.2004.02183.x. PMID:15361138 doi:https://dx.doi.org/10.1111/j.1365-313X.2004.02183.x
↑ Bernhardt C, Zhao M, Gonzalez A, Lloyd A, Schiefelbein J. The bHLH genes GL3 and EGL3 participate in an intercellular regulatory circuit that controls cell patterning in the Arabidopsis root epidermis. Development. 2005 Jan;132(2):291-8. Epub 2004 Dec 8. PMID:15590742 doi:https://dx.doi.org/dev.01565

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OCA

[1] Payne CT, Zhang F, Lloyd AM. GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1. Genetics. 2000 Nov;156(3):1349-62. PMID:11063707 doi:10.1093/genetics/156.3.1349

[2] Zhang F, Gonzalez A, Zhao M, Payne CT, Lloyd A. A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis. Development. 2003 Oct;130(20):4859-69. Epub 2003 Aug 13. PMID:12917293 doi:https://dx.doi.org/10.1242/dev.00681

[3] Ramsay NA, Walker AR, Mooney M, Gray JC. Two basic-helix-loop-helix genes (MYC-146 and GL3) from Arabidopsis can activate anthocyanin biosynthesis in a white-flowered Matthiola incana mutant. Plant Mol Biol. 2003 Jun;52(3):679-88. doi: 10.1023/a:1024852021124. PMID:12956536 doi:https://dx.doi.org/10.1023/a:1024852021124

[4] Esch JJ, Chen M, Sanders M, Hillestad M, Ndkium S, Idelkope B, Neizer J, Marks MD. A contradictory GLABRA3 allele helps define gene interactions controlling trichome development in Arabidopsis. Development. 2003 Dec;130(24):5885-94. PMID:14561633 doi:10.1242/dev.00812

[5] Bernhardt C, Lee MM, Gonzalez A, Zhang F, Lloyd A, Schiefelbein J. The bHLH genes GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) specify epidermal cell fate in the Arabidopsis root. Development. 2003 Dec;130(26):6431-9. Epub 2003 Nov 19. PMID:14627722 doi:https://dx.doi.org/10.1242/dev.00880

[6] Zimmermann IM, Heim MA, Weisshaar B, Uhrig JF. Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins. Plant J. 2004 Oct;40(1):22-34. doi: 10.1111/j.1365-313X.2004.02183.x. PMID:15361138 doi:https://dx.doi.org/10.1111/j.1365-313X.2004.02183.x

[7] Bernhardt C, Zhao M, Gonzalez A, Lloyd A, Schiefelbein J. The bHLH genes GL3 and EGL3 participate in an intercellular regulatory circuit that controls cell patterning in the Arabidopsis root epidermis. Development. 2005 Jan;132(2):291-8. Epub 2004 Dec 8. PMID:15590742 doi:https://dx.doi.org/dev.01565

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9c7n is ON HOLD
+==Crystal Structure of the GL3 ACT-like Domain==
+<StructureSection load='9c7n' size='340' side='right'caption='[[9c7n]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-Authors: Ghanbarpour, A., Lee, Y.S., Silwal, J., Geiger, J.H., Grotewold, E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9c7n]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9C7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9C7N FirstGlance]. <br>
-Description: Crystal Structure of the GL3 ACT-like Domain
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9c7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9c7n OCA], [https://pdbe.org/9c7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9c7n RCSB], [https://www.ebi.ac.uk/pdbsum/9c7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9c7n ProSAT]</span></td></tr>
-[[Category: Geiger, J.H]]
+</table>
-[[Category: Silwal, J]]
+== Function ==
-[[Category: Lee, Y.S]]
+[https://www.uniprot.org/uniprot/GL3_ARATH GL3_ARATH] Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Negatively regulates stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication. Also regulates trichome cell wall maturation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Also seems to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Activates the transcription of GL2.<ref>PMID:11063707</ref> <ref>PMID:12917293</ref> <ref>PMID:12956536</ref> <ref>PMID:14561633</ref> <ref>PMID:14627722</ref> <ref>PMID:15361138</ref> <ref>PMID:15590742</ref>
-[[Category: Grotewold, E]]
+== References ==
-[[Category: Ghanbarpour, A]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arabidopsis thaliana]]
+[[Category: Large Structures]]
+[[Category: Geiger JH]]
+[[Category: Ghanbarpour A]]
+[[Category: Grotewold E]]
+[[Category: Lee YS]]
+[[Category: Silwal J]]

9c7n: Difference between revisions

Latest revision as of 07:17, 8 October 2025

Crystal Structure of the GL3 ACT-like Domain

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