1wf8: Difference between revisions
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New page: left|200px<br /> <applet load="1wf8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wf8" /> '''Solution structure of the PDZ domain of Spi... |
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== | ==Solution structure of the PDZ domain of Spinophilin/NeurabinII protein== | ||
<StructureSection load='1wf8' size='340' side='right'caption='[[1wf8]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1wf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WF8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wf8 OCA], [https://pdbe.org/1wf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wf8 RCSB], [https://www.ebi.ac.uk/pdbsum/1wf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wf8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wf8 TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NEB1_HUMAN NEB1_HUMAN] Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/1wf8_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wf8 ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Hayashi | [[Category: Hayashi F]] | ||
[[Category: Qin | [[Category: Qin X]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Yokoyama | |||
Latest revision as of 13:36, 9 May 2024
Solution structure of the PDZ domain of Spinophilin/NeurabinII protein
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