9fql: Difference between revisions

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New page: '''Unreleased structure''' The entry 9fql is ON HOLD Authors: Buratto, J., Mauran, L., Goudreau, S., Guichard, G. Description: Crystal structure of hDM2 in complex with a peptidic liga...
 
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'''Unreleased structure'''


The entry 9fql is ON HOLD
==Crystal structure of hDM2 in complex with a peptidic ligand containing a di-urea insert.==
 
<StructureSection load='9fql' size='340' side='right'caption='[[9fql]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
Authors: Buratto, J., Mauran, L., Goudreau, S., Guichard, G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9fql]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FQL FirstGlance]. <br>
Description: Crystal structure of hDM2 in complex with a peptidic ligand containing a di-urea insert.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2Z:[(2~{S})-2-azanylpropyl]carbamic+acid'>G2Z</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=URL:[(2~{S})-2-azanyl-4-methyl-pentyl]carbamic+acid'>URL</scene></td></tr>
[[Category: Mauran, L]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fql OCA], [https://pdbe.org/9fql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fql RCSB], [https://www.ebi.ac.uk/pdbsum/9fql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fql ProSAT]</span></td></tr>
[[Category: Goudreau, S]]
</table>
[[Category: Guichard, G]]
== Disease ==
[[Category: Buratto, J]]
[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
== Function ==
[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Buratto J]]
[[Category: Goudreau S]]
[[Category: Guichard G]]
[[Category: Mauran L]]
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