9ccc: Difference between revisions

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~~'''Unreleased structure'''~~

~~The~~ entry ~~9ccc~~ is ~~ON HOLD~~

==Crystal structure of human dihydroorotate dehydrogenase with new alkyne ligand==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9ccc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CCC OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9CCC FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AVV:~{N}-[4-[2-(3-aminophenyl)ethynyl]phenyl]ethanamide'>A1AVV</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ccc OCA], [https://pdbe.org/9ccc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ccc RCSB], [https://www.ebi.ac.uk/pdbsum/9ccc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ccc ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>

== Function ==

[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Andrade CH]]

[[Category: Emery FS]]

[[Category: Nonato MC]]

[[Category: Purificacao AD]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ccc is ON HOLD
+==Crystal structure of human dihydroorotate dehydrogenase with new alkyne ligand==
+<StructureSection load='9ccc' size='340' side='right'caption='[[9ccc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ccc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CCC FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AVV:~{N}-[4-[2-(3-aminophenyl)ethynyl]phenyl]ethanamide'>A1AVV</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ccc OCA], [https://pdbe.org/9ccc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ccc RCSB], [https://www.ebi.ac.uk/pdbsum/9ccc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ccc ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Andrade CH]]
+[[Category: Emery FS]]
+[[Category: Nonato MC]]
+[[Category: Purificacao AD]]