Intercellular adhesion molecule

spinqualitylabelsall models Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code 1mq8). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation. ICAM contains 5 Ig-like domains. ICAM-1 is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system. ICAM-2 mediates adhesive interactions important for antigen-specific immune response. ICAM-3 acts as recognition receptor in the phagocytosis of macrophages in engulfment of apoptotic neutrophils. ICAM-5 has 2 types of binding activities: binding between neutrons and binding between neuron and leukocytes. Disease ICAM mutation is involved in multiple sclerosis.

3D structures of intercellular adhesion molecule

Updated on 04-July-2024

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• ICAM-1 (CD54)
  • 1iam, 1ic1, 1d3l – hICAM N terminal domain – human
    
  • 1p53 – hICAM domain 3-5
    
• ICAM-1 complexes
  • 1d3e, 1d3i – hICAM N terminal domain + rhinovirus coat proteins - CryoEM
    
  • 7bg7 – hICAM + rhinovirus polyproteins - CryoEM
    
  • 1mq8 – hICAM domain 1-2 + LFA-1
    
  • 3tcx – hICAM domain 1 + LFA-1
    
  • 6eit – hICAM domain 1-2 + coxsakievirus coat proteins - CryoEM
    
  • 1z7z – hICAM domain 1-5 + coxsakievirus coat proteins - CryoEM
    
  • 2oz4 – hICAM domain 4 + antibody
    
  • 5mza, 6s8u – hICAM residues 28-212 + erythrocyte membrane protein 1
    
• ICAM-2
  • 1zxq – hICAM extracellular domain
    
• ICAM-3
  • 1t0p – hICAM N terminal domain + LFA-1
    
• ICAM-5
  • 3bn3 – hICAM N terminal domain + LFA-1
    
  • 4oi9, 4oia, 4oib – hICAM domain D1-D4
    

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Michal Harel