9g08: Difference between revisions

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New page: '''Unreleased structure''' The entry 9g08 is ON HOLD Authors: Description: Category: Unreleased Structures
 
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'''Unreleased structure'''


The entry 9g08 is ON HOLD
==Structure of human RNF213 bound to the secreted effector IpaH1.4 from Shigella flexneri==
 
<StructureSection load='9g08' size='340' side='right'caption='[[9g08]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9g08]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Shigella_flexneri_5a_str._M90T Shigella flexneri 5a str. M90T]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9G08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9G08 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9g08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9g08 OCA], [https://pdbe.org/9g08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9g08 RCSB], [https://www.ebi.ac.uk/pdbsum/9g08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9g08 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RN213_HUMAN RN213_HUMAN] Moyamoya disease. Disease susceptibility is associated with variants affecting the gene represented in this entry.  A chromosomal aberration involving RNF213 is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALK.<ref>PMID:12112524</ref>
== Function ==
[https://www.uniprot.org/uniprot/RN213_HUMAN RN213_HUMAN] Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115).<ref>PMID:21799892</ref> <ref>PMID:26126547</ref> <ref>PMID:26278786</ref> <ref>PMID:26766444</ref> <ref>PMID:30705059</ref> <ref>PMID:30846318</ref> <ref>PMID:32139119</ref> <ref>PMID:33842849</ref> <ref>PMID:34012115</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Shigella flexneri 5a str. M90T]]
[[Category: Naydenova K]]
[[Category: Randow F]]
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