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Below are listed pages in Proteopedia about evolutionary conservation, how to use the [http://consurf.tau.ac.il ConSurf Server], and how to interpret its results to identify functional sites in proteins. | Below are listed pages in Proteopedia about evolutionary conservation, how to use the [http://consurf.tau.ac.il ConSurf Server], and how to interpret its results to identify functional sites in proteins. | ||
==Principles== | ==Principles== | ||
* [[Introduction to Evolutionary Conservation]] ( | * [[Introduction to Evolutionary Conservation]] (88K*): an explanation starting at the beginning, with examples. | ||
* [[Conservation, Evolutionary]] covers | * [[Conservation, Evolutionary]] (141K*) covers | ||
** How to locate conserved and variable patches | ** How to locate conserved and variable patches | ||
** Conservation expected to support folding of domains | ** Conservation expected to support folding of domains | ||
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==Practical== | ==Practical== | ||
* There are [http://firstglance.jmol.org/notes.htm#consurffg many advantages] of using FirstGlance in Jmol to visualize and analyze conservation patterns from the ConSurf Server. | * There are [http://firstglance.jmol.org/notes.htm#consurffg many advantages] of using FirstGlance in Jmol to visualize and analyze conservation patterns from the ConSurf Server. | ||
* [[How to see conserved regions]] lists options and how to get started. | * [[How to see conserved regions]] (19K*) lists options and how to get started. | ||
* [[ConSurf Quick Analysis Procedure]]: step by step for submitting a job to ConSurf. | * [[ConSurf Quick Analysis Procedure]] (11K*): step by step for submitting a job to ConSurf. | ||
* [[ConSurfDB vs. ConSurf]] | * [[ConSurfDB vs. ConSurf]] (45K*) Explains how to discover key conserved residues by using ConSurf settings that limit the multiple sequence alignment to proteins with the same function as the query, with illustrated cases. ConSurf results based on default settings often obscure conservation specific to the function of the protein. Also summarizes the mechanisms of the ConSurf Server and the ConSurf Database. | ||
* [[FirstGlance/Visualizing Conservation]] [[Image:New yellow1.gif]] January, 2022. Demonstrates the conveniences offered by FirstGlance for easily seeing conservation of [[salt bridges]], [[cation-pi interactions]], residues that bind ligand, substrate, or inhibitor, residues in covalent protein crosslinks, or any residues that you specify. | * [[FirstGlance/Visualizing Conservation]] [[Image:New yellow1.gif]] January, 2022 (11K*). Demonstrates the conveniences offered by FirstGlance for easily seeing conservation of [[salt bridges]], [[cation-pi interactions]], residues that bind ligand, substrate, or inhibitor, residues in covalent protein crosslinks, or any residues that you specify. | ||
* [[Interpreting ConSurf Results]] [[Image:New yellow1.gif]] January, 2022. How to tell whether a ConSurf result is optimal. | * [[Interpreting ConSurf Results]] [[Image:New yellow1.gif]] January, 2022 (7K*). How to tell whether a ConSurf result is optimal. | ||
* [[Help:How to Insert a ConSurf Result Into a Proteopedia Green Link]] | * [[Help:How to Insert a ConSurf Result Into a Proteopedia Green Link]] (5K*) | ||
===Page Views=== | ===Page Views=== | ||
[[Image:Asteriskinline.png]] K* (kilo) numbers in parentheses are the numbers of page views as of August, 2025. In total, Proteopedia | |||
pages about ConSurf had been viewed more than 300,000 times by August, 2025. | |||
==See Also== | ==See Also== | ||
*[[Index pages]] | *[[Index pages]] | ||
