1wlx: Difference between revisions
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New page: left|200px<br /> <applet load="1wlx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wlx" /> '''Solution structure of the third spectrin re... |
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== | ==Solution structure of the third spectrin repeat of alpha-actinin-4== | ||
<StructureSection load='1wlx' size='340' side='right'caption='[[1wlx]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1wlx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WLX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wlx OCA], [https://pdbe.org/1wlx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wlx RCSB], [https://www.ebi.ac.uk/pdbsum/1wlx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wlx ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/ACTN4_HUMAN ACTN4_HUMAN] Defects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1) [MIM:[https://omim.org/entry/603278 603278]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:10700177</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ACTN4_HUMAN ACTN4_HUMAN] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/1wlx_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wlx ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Actinin 3D structures|Actinin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Booker | [[Category: Booker GW]] | ||
[[Category: Kowalski | [[Category: Kowalski K]] | ||
[[Category: Merkel | [[Category: Merkel AL]] | ||
Latest revision as of 13:44, 9 May 2024
Solution structure of the third spectrin repeat of alpha-actinin-4
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