1sz6: Difference between revisions

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[[Image:1sz6.gif|left|200px]]


<!--
==MISTLETOE LECTIN I FROM VISCUM ALBUM. CRYSTAL STRUCTURE AT 2.05 A RESOLUTION==
The line below this paragraph, containing "STRUCTURE_1sz6", creates the "Structure Box" on the page.
<StructureSection load='1sz6' size='340' side='right'caption='[[1sz6]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1sz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SZ6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1sz6|  PDB=1sz6  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sz6 OCA], [https://pdbe.org/1sz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sz6 RCSB], [https://www.ebi.ac.uk/pdbsum/1sz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sz6 ProSAT]</span></td></tr>
 
</table>
'''MISTLETOE LECTIN I FROM VISCUM ALBUM. CRYSTAL STRUCTURE AT 2.05 A RESOLUTION'''
== Function ==
 
[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZ6 OCA].  
Check<jmol>
[[Category: Betzel, C.]]
  <jmolCheckbox>
[[Category: Gabdoulkhakov, A G.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sz/1sz6_consurf.spt"</scriptWhenChecked>
[[Category: Guhlistova, N E.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Krauspenhaar, R.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Lyashenko, A V.]]
  </jmolCheckbox>
[[Category: Mikhailov, A M.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sz6 ConSurf].
[[Category: Nikonov, S V.]]
<div style="clear:both"></div>
[[Category: Stoeva, S.]]
== References ==
[[Category: Voelter, W.]]
<references/>
[[Category: Ribosome-inactivating protein type ii]]
__TOC__
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:18:03 2008''
</StructureSection>
[[Category: Large Structures]]
[[Category: Viscum album]]
[[Category: Betzel C]]
[[Category: Gabdoulkhakov AG]]
[[Category: Guhlistova NE]]
[[Category: Krauspenhaar R]]
[[Category: Lyashenko AV]]
[[Category: Mikhailov AM]]
[[Category: Nikonov SV]]
[[Category: Stoeva S]]
[[Category: Voelter W]]
Retrieved from "https://proteopedia.org/1sz6"