9cu8: Difference between revisions
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New page: '''Unreleased structure''' The entry 9cu8 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Crystal Structure of TNFR2 TNFR2_mb1 Complex== | |||
<StructureSection load='9cu8' size='340' side='right'caption='[[9cu8]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9cu8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CU8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cu8 OCA], [https://pdbe.org/9cu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cu8 RCSB], [https://www.ebi.ac.uk/pdbsum/9cu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cu8 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TNR1B_HUMAN TNR1B_HUMAN] Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.<ref>PMID:14688072</ref> <ref>PMID:12370298</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Baker D]] | |||
[[Category: Bera AK]] | |||
[[Category: Glogl M]] | |||
Latest revision as of 06:20, 4 December 2024
Crystal Structure of TNFR2 TNFR2_mb1 Complex
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