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New page: left|200px<br /> <applet load="1jvb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jvb, resolution 1.85Å" /> '''ALCOHOL DEHYDROGENA...
 
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[[Image:1jvb.gif|left|200px]]<br />
<applet load="1jvb" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1jvb, resolution 1.85&Aring;" />
'''ALCOHOL DEHYDROGENASE FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS'''<br />


==Overview==
==ALCOHOL DEHYDROGENASE FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS==
The crystal structure of a medium-chain NAD(H)-dependent alcohol, dehydrogenase (ADH) from an archaeon has been solved by multiwavelength, anomalous diffraction, using a selenomethionine-substituted enzyme. The, protein (SsADH), extracted from the hyperthermophilic organism Sulfolobus, solfataricus, is a homo-tetramer with a crystallographic 222 symmetry., Despite the low level of sequence identity, the overall fold of the, monomer is similar to that of the other homologous ADHs of known, structure. However, a significant difference is the orientation of the, catalytic domain relative to the coenzyme-binding domain that results in a, larger interdomain cleft. At the bottom of this cleft, the catalytic zinc, ion is coordinated tetrahedrally and lacks the zinc-bound water molecule, that is ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12051852 (full description)]]
<StructureSection load='1jvb' size='340' side='right'caption='[[1jvb]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1jvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JVB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvb OCA], [https://pdbe.org/1jvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jvb RCSB], [https://www.ebi.ac.uk/pdbsum/1jvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jvb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ADH_SACS2 ADH_SACS2]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/1jvb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jvb ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1JVB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JVB OCA]].
*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus at 1.85 A resolution., Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A, J Mol Biol. 2002 Apr 26;318(2):463-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12051852 12051852]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Saccharolobus solfataricus]]
[[Category: Sulfolobus solfataricus]]
[[Category: Esposito L]]
[[Category: Esposito, L.]]
[[Category: Mazzarella L]]
[[Category: Mazzarella, L.]]
[[Category: Sica F]]
[[Category: Sica, F.]]
[[Category: Zagari A]]
[[Category: Zagari, A.]]
[[Category: ZN]]
[[Category: archaeon]]
[[Category: nad]]
[[Category: zinc]]
 
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Retrieved from "https://proteopedia.org/1jvb"