Pyruvate dehydrogenase kinase: Difference between revisions
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== Function == | == Function == | ||
'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>. | '''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>. | ||
*'''PDK1''' is abundant in heart cells. | *'''PDK1''' is abundant in heart cells. PDK1 expression was found to predict future major adverse cardiovascular events<ref>PMID:36866436</ref>. | ||
*'''PDK2''' is abundant in mitochondria. | *'''PDK2''' is abundant in mitochondria. | ||
*'''PDK3''' is abundant in testis. | *'''PDK3''' is abundant in testis. | ||
*'''PDK4''' is abundant in muscle and heart. It is important during starvation for regulation of pyruvate dehydrogenate complex activity and glucose homoeostasis<ref>PMID:16606348</ref> | *'''PDK4''' is abundant in muscle and heart. It is important during starvation for regulation of pyruvate dehydrogenate complex activity and glucose homoeostasis<ref>PMID:16606348</ref>. | ||
== Relevance == | == Relevance == | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of pyruvate dehydrogenase kinase== | ==3D structures of pyruvate dehydrogenase kinase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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**[[2bu7]] - hPDK2 + acetamide derivative<br /> | **[[2bu7]] - hPDK2 + acetamide derivative<br /> | ||
**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR /> | **[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR /> | ||
**[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]], [[5m4k]], [[5m4m]], [[5m4n]], [[5m4p]], [[6lil]], [[6lio]], [[6lin]], [[ | **[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]], [[5j6a]], [[5j71]], [[5m4k]], [[5m4m]], [[5m4n]], [[5m4p]], [[6lil]], [[6lio]], [[6lin]], [[6tmp]], [[6tmq]], [[6tmz]], [[6tn0]], [[6tn2]], [[7eas]], [[7ebh]], [[7vbu]], [[7vbv]], [[7vbx]], [[8zm1]], [[8zm2]], [[9m3o]], [[9m3p]], [[9m3r]], [[9m3t]], [[9m3u]] – hPDK2 + inhibitor<br /> | ||
**[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2<br /> | **[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2<br /> | ||
**[[1jm6]] – PDK2 + ADP – rat<br /> | **[[1jm6]] – PDK2 + ADP – rat<br /> | ||
