Resolvase

spinqualitylabelsall models Yeast Holliday junction resolvase dimer complex with sulfate, 1kcf Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Resolvase or recombinase (Rec) is a nuclease which is involved in DNA recombination. According to the binding residue, the recombinases are grouped to Tyr- and Ser-recombinase. Holliday junction resolvase (HJR) resolves 4-way DNA intermediates known as Holliday junctions. Recombination of 2 DNA sites occurs when recombinase binds to the 2 strands. Tyr-recombinases include Cre which recombines loxP sites, FLP and lambda integrase (LamInt). Ser-recombinases (S-rec) include gamma-delta resolvase (GDR), Tn3 resolvase and phiC31 integrase. RadA recombinase promotes DNA recombination. Detailed analysis of its dimeric structure suggests mechanisms for junction isomerization and communication between the two active sites . RadB recombinase is a paralogue of RadA assisting in RadA-mediated strand exchange . Hin-recombinase (HRec) is a protein of Salmonella. HRec inverts a 900 base pair DNA segment which contains the promoters of flagellar genes. The inversion changes the these genes' expressions. Tre recombinase recognizes a target sequence of the HIV virus resulting in excision and eradication of the provirus from infected human cells . 3D structures of resolvase Resolvase 3D structures

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