9iyw: Difference between revisions
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New page: '''Unreleased structure''' The entry 9iyw is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Crystal structure of chimeric KSQ-AT didomain== | |||
<StructureSection load='9iyw' size='340' side='right'caption='[[9iyw]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9iyw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_graminofaciens Streptomyces graminofaciens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IYW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9iyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9iyw OCA], [https://pdbe.org/9iyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9iyw RCSB], [https://www.ebi.ac.uk/pdbsum/9iyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9iyw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GFSA_STRHA GFSA_STRHA] First protein in the synthesis of the 16-membered macrolide antibiotics FD-891 and FD-892 (PubMed:20589823). Composed of 5 modules; the first is a loading module (LM) that synthesizes a starter unit used by the first elongation module for polyketide chain elongation (PubMed:34985877, PubMed:37216195). The starter unit is extended by multiple rounds of addition of malonyl-CoA or methylmalonyl-CoA, and other modifications to help generate the final products (Probable) (PubMed:20589823). The loading module (residues 1-927, LM with an inactive acyltransferase domain) preferentially decarboxylates malonyl-GfsA acyl carrier protein of the LM (ACP-LM) over methylmalonyl-GfsA ACP-LM and has no activity on malonyl-CoA or methymalonyl-CoA (PubMed:34985877). LM decarboxylates malonyl-ACP-LM better than the malonyl-ACP-1 module of GfsA (i.e. the next module in the same protein) and has no activity on other malonyl-ACP modules (PubMed:37216195).<ref>PMID:20589823</ref> <ref>PMID:34985877</ref> <ref>PMID:37216195</ref> <ref>PMID:20589823</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptomyces graminofaciens]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Chisuga T]] | |||
[[Category: Miyanaga A]] | |||
Latest revision as of 05:40, 6 August 2025
Crystal structure of chimeric KSQ-AT didomain
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