9cyp: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 9cyp is ON HOLD Authors: Ebrahim, A., Perdikari, A., Woods, V.A., Lawler, K., Bounds, R., Singh, N.I., Mehlman, T., Riley, B.T., Sharma, S., Morris,... |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K)== | |||
<StructureSection load='9cyp' size='340' side='right'caption='[[9cyp]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9cyp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CYP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cyp OCA], [https://pdbe.org/9cyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cyp RCSB], [https://www.ebi.ac.uk/pdbsum/9cyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cyp ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
[[Category: Farooqi | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Morris | [[Category: Bounds R]] | ||
[[Category: Perdikari | [[Category: Ebrahim A]] | ||
[[Category: | [[Category: Farooqi IS]] | ||
[[Category: | [[Category: Henning E]] | ||
[[Category: | [[Category: Keedy DA]] | ||
[[Category: | [[Category: Keogh JM]] | ||
[[Category: Lawler K]] | |||
[[Category: Mehlman T]] | |||
[[Category: Morris JW]] | |||
[[Category: Perdikari A]] | |||
[[Category: Riley BT]] | |||
[[Category: Sharma S]] | |||
[[Category: Singh NI]] | |||
[[Category: Smith M]] | |||
[[Category: Woods VA]] | |||
Latest revision as of 13:10, 21 August 2024
Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K)
| ||||||||||||
