9cyz: Difference between revisions
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New page: '''Unreleased structure''' The entry 9cyz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures |
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==Crystal structure of human farnesyl pyrophosphate synthase in complex with a cryptic pocket ligand, CL02134== | |||
<StructureSection load='9cyz' size='340' side='right'caption='[[9cyz]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9cyz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CYZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.302Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YL2:({[6-(4-CYCLOPROPYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]AMINO}METHANEDIYL)BIS(PHOSPHONIC+ACID)'>YL2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cyz OCA], [https://pdbe.org/9cyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cyz RCSB], [https://www.ebi.ac.uk/pdbsum/9cyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cyz ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Pandya VR]] | |||
[[Category: Park J]] | |||
Latest revision as of 07:07, 29 October 2025
Crystal structure of human farnesyl pyrophosphate synthase in complex with a cryptic pocket ligand, CL02134
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