9d0y: Difference between revisions
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==Map of endoH-treated hemagglutinin A/Sing/INFIMH/16== | |||
<StructureSection load='9d0y' size='340' side='right'caption='[[9d0y]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9d0y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9D0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9D0Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9d0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9d0y OCA], [https://pdbe.org/9d0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9d0y RCSB], [https://www.ebi.ac.uk/pdbsum/9d0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9d0y ProSAT]</span></td></tr> | ||
[[Category: Torrents | </table> | ||
[[Category: De Paiva Froes Rocha | == Function == | ||
[https://www.uniprot.org/uniprot/A0A2R4U332_9INFA A0A2R4U332_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[ARBA:ARBA00059860][RuleBase:RU003324] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Aequorea victoria]] | |||
[[Category: Influenza A virus]] | |||
[[Category: Large Structures]] | |||
[[Category: Torrents de la Pena A]] | |||
[[Category: Ward AB]] | |||
[[Category: De Paiva Froes Rocha R]] | |||
Latest revision as of 08:08, 13 August 2025
Map of endoH-treated hemagglutinin A/Sing/INFIMH/16
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