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New page: '''Unreleased structure''' The entry 9gem is ON HOLD Authors: Koekemoer, L., Gurav, N., Apostolidou, M., Adcock, C., McGown, A., Spencer, J., Huber, K.V.M. Description: Crystal structu...
 
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'''Unreleased structure'''


The entry 9gem is ON HOLD
==Crystal structure of NUDT14 complexed with novel compound MA12==
 
<StructureSection load='9gem' size='340' side='right'caption='[[9gem]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
Authors: Koekemoer, L., Gurav, N., Apostolidou, M., Adcock, C., McGown, A., Spencer, J., Huber, K.V.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9gem]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GEM FirstGlance]. <br>
Description: Crystal structure of NUDT14 complexed with novel compound MA12
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.015&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IJI:1-(1-methylpiperidin-4-yl)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]pyrazolo[3,4-d]pyrimidin-4-amine'>A1IJI</scene></td></tr>
[[Category: Gurav, N]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gem OCA], [https://pdbe.org/9gem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gem RCSB], [https://www.ebi.ac.uk/pdbsum/9gem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gem ProSAT]</span></td></tr>
[[Category: Koekemoer, L]]
</table>
[[Category: Adcock, C]]
== Function ==
[[Category: Apostolidou, M]]
[https://www.uniprot.org/uniprot/NUD14_HUMAN NUD14_HUMAN] Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
[[Category: Spencer, J]]
__TOC__
[[Category: Mcgown, A]]
</StructureSection>
[[Category: Huber, K.V.M]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Adcock C]]
[[Category: Apostolidou M]]
[[Category: Dlamini LS]]
[[Category: Gurav N]]
[[Category: Huber KVM]]
[[Category: Koekemoer L]]
[[Category: McGown A]]
[[Category: Spencer J]]
Retrieved from "https://proteopedia.org/9gem"