9j2x: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9j2x is ~~ON HOLD~~

==Human cGAS catalytic domain bound with RU.521==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9j2x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J2X OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9J2X FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEV:2-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-5-methyl-4-[(1~{R})-3-oxidanylidene-1~{H}-2-benzofuran-1-yl]-1~{H}-pyrazol-3-one'>AEV</scene>, <scene name='pdbligand=LLS:(3~{S})-3-[1-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-3-methyl-5-oxidanyl-pyrazol-4-yl]-3~{H}-2-benzofuran-1-one'>LLS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9j2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j2x OCA], [https://pdbe.org/9j2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j2x RCSB], [https://www.ebi.ac.uk/pdbsum/9j2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j2x ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Li MJ]]

[[Category: Xu YC]]

[[Category: Zhao WF]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9j2x is ON HOLD
+==Human cGAS catalytic domain bound with RU.521==
+<StructureSection load='9j2x' size='340' side='right'caption='[[9j2x]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9j2x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J2X FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEV:2-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-5-methyl-4-[(1~{R})-3-oxidanylidene-1~{H}-2-benzofuran-1-yl]-1~{H}-pyrazol-3-one'>AEV</scene>, <scene name='pdbligand=LLS:(3~{S})-3-[1-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-3-methyl-5-oxidanyl-pyrazol-4-yl]-3~{H}-2-benzofuran-1-one'>LLS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j2x OCA], [https://pdbe.org/9j2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j2x RCSB], [https://www.ebi.ac.uk/pdbsum/9j2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j2x ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li MJ]]
+[[Category: Xu YC]]
+[[Category: Zhao WF]]