Synapsin: Difference between revisions
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'''Synapsins''' (SYN) are neuronal phosphoproteins which modulate neurotransmitter release at the pre-synaptic terminal by reversibly tethering synaptic vescicles to the actin cytoskeleton<ref>PMID:20438797</ref>. | '''Synapsins''' (SYN) are neuronal phosphoproteins which modulate neurotransmitter release at the pre-synaptic terminal by reversibly tethering synaptic vescicles to the actin cytoskeleton<ref>PMID:20438797</ref>. | ||
*'''Synapsin 1''' is involved in synapse formation<ref>PMID:9513186</ref>. | |||
*'''Synapsin 2''' is involved in axon formation. | |||
*'''Synapsin 3''' is involved in regulation of dopaminergic neurotransmission<ref>PMID:21827867</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both <scene name='84/843883/Cv/4'>hydrogen bonds</scene> and <scene name='84/843883/Cv/5'>Van-der Waals contacts</scene> with the protein<ref>PMID:14688264</ref>. Water molecules are shown as red spheres. | The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both <scene name='84/843883/Cv/4'>hydrogen bonds</scene> and <scene name='84/843883/Cv/5'>Van-der Waals contacts</scene> with the protein<ref>PMID:14688264</ref>. Water molecules are shown as red spheres. | ||
==3D structures of synapsin== | ==3D structures of synapsin== | ||
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== References == | == References == | ||
<references/> | <references/> | ||
</StructureSection> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 07:47, 15 August 2024
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