9d9d: Difference between revisions
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New page: '''Unreleased structure''' The entry 9d9d is ON HOLD Authors: Kuntz, D.A., Prive, G.G. Description: Candida albicans Hsp90 nucleotide binding domain in complex with BRI2216 [[Category:... |
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==Candida albicans Hsp90 nucleotide binding domain in complex with BRI2216== | |||
<StructureSection load='9d9d' size='340' side='right'caption='[[9d9d]], [[Resolution|resolution]] 2.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9d9d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9D9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9D9D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1A28:3-azanyl-~{N}-[1-[(2~{R})-2-[2,4-bis(fluoranyl)phenyl]-2-oxidanyl-3-(1,2,4-triazol-1-yl)propyl]piperidin-4-yl]-2-oxidanylidene-1-(4-phenyl-2,3-dihydro-1,4-benzoxazin-6-yl)thieno[2,3-b]pyrazine-6-carboxamide'>A1A28</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9d9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9d9d OCA], [https://pdbe.org/9d9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9d9d RCSB], [https://www.ebi.ac.uk/pdbsum/9d9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9d9d ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HSP90_CANAL HSP90_CANAL] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Candida albicans SC5314]] | |||
[[Category: Large Structures]] | |||
[[Category: Kuntz DA]] | |||
[[Category: Prive GG]] | |||
