9d9i: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9d9i is ~~ON HOLD~~

==Human Hsp90b nucleotide binding domain in complex with BRI2312==

~~Authors~~: ~~Kuntz~~, D.A., ~~Prive~~, G.G.

== Structural highlights ==

<table><tr><td colspan='2'>[[9d9i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9D9I OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9D9I FirstGlance].

~~Description~~: ~~Human Hsp90b nucleotide binding domain~~ in ~~complex~~ with ~~BRI2312~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1A24:3-azanyl-6-[[[1-[(2~{R})-2-[2,4-bis(fluoranyl)phenyl]-2-oxidanyl-3-(1,2,4-triazol-1-yl)propyl]piperidin-4-yl]amino]methyl]-1-(4-phenyl-2,3-dihydro-1,4-benzoxazin-6-yl)thieno[2,3-b]pyrazin-2-one'>A1A24</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>

[[Category: ~~Prive, G.G~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9d9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9d9i OCA], [https://pdbe.org/9d9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9d9i RCSB], [https://www.ebi.ac.uk/pdbsum/9d9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9d9i ProSAT]</td></tr>

[[Category: ~~Kuntz, D.A~~]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Kuntz DA]]

[[Category: Prive GG]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9d9i is ON HOLD
+==Human Hsp90b nucleotide binding domain in complex with BRI2312==
+<StructureSection load='9d9i' size='340' side='right'caption='[[9d9i]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Kuntz, D.A., Prive, G.G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9d9i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9D9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9D9I FirstGlance]. <br>
-Description: Human Hsp90b nucleotide binding domain in complex with BRI2312
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1A24:3-azanyl-6-[[[1-[(2~{R})-2-[2,4-bis(fluoranyl)phenyl]-2-oxidanyl-3-(1,2,4-triazol-1-yl)propyl]piperidin-4-yl]amino]methyl]-1-(4-phenyl-2,3-dihydro-1,4-benzoxazin-6-yl)thieno[2,3-b]pyrazin-2-one'>A1A24</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-[[Category: Prive, G.G]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9d9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9d9i OCA], [https://pdbe.org/9d9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9d9i RCSB], [https://www.ebi.ac.uk/pdbsum/9d9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9d9i ProSAT]</span></td></tr>
-[[Category: Kuntz, D.A]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Kuntz DA]]
+[[Category: Prive GG]]