High mobility group protein: Difference between revisions

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<StructureSection load='2gzk' size='340' side='right' caption='Rat HMGB1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''>
<StructureSection load='2gzk' size='340' side='right' caption='Rat HMGB1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''>
== Function ==
== Function ==
'''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and regulator transcription.  HMG superfamilies differ by their DNA-binding domains.<br />
'''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and regulates transcription.  HMG superfamilies differ by their DNA-binding domains.<br />
* '''HMGA'''s bind via an AT-hook domain.  For details on HMGA see [[HMGI(Y)]].<br />
* '''HMGA'''s bind via an AT-hook domain.  For details on HMGA see [[HMGI(Y)]].<br />
* '''HMGB'''s bind via box domain<ref>PMID:17979838</ref>.<br />
* '''HMGB'''s bind via box domain<ref>PMID:17979838</ref>.<br />
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**[[6cij]], [[6cik]], [[6cil]], [[6cim]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA<br />
**[[6cij]], [[6cik]], [[6cil]], [[6cim]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA<br />
**[[6cg0]], [[6oem]], [[6oen]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br />
**[[6cg0]], [[6oem]], [[6oen]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br />
**[[8i9m]] – hHMG-1 89-183 + RAGE – Cryo EM<br />
**[[9cg9]] – hHMG-1 + nucleosome – Cryo EM<br />
**[[2eqz]], [[2yqi]] – hHMG-3 box domain - NMR<br />
**[[2eqz]], [[2yqi]] – hHMG-3 box domain - NMR<br />
**[[1j3d]] – pHMG-2 C terminal – pig - NMR<br />
**[[1j3d]] – pHMG-2 C terminal – pig - NMR<br />
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**[[1ckt]], [[4qr9]] – rHMG-1 A domain + DNA <br />
**[[1ckt]], [[4qr9]] – rHMG-1 A domain + DNA <br />
**[[2gzk]] – rHMG-1 tandem boxes + DNA <br />
**[[2gzk]] – rHMG-1 tandem boxes + DNA <br />
**[[5ze2]], [[5ze1]], [[5ze0]], [[5zdz]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – mouse<br />
**[[5zdz]], [[5ze0]], [[5ze1]], [[5ze2]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – mouse<br />
**[[6oeo]], [[6oer]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br />
**[[6oeo]], [[6oer]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br />
**[[1hsm]], [[1hsn]], [[1nhm]], [[1nhn]] – HMG-1 box domain – chinese hamster - NMR <br />
**[[1hsm]], [[1hsn]], [[1nhm]], [[1nhn]] – HMG-1 box domain – chinese hamster - NMR <br />
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