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| **[[6cij]], [[6cik]], [[6cil]], [[6cim]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA<br /> | | **[[6cij]], [[6cik]], [[6cil]], [[6cim]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA<br /> |
| **[[6cg0]], [[6oem]], [[6oen]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br /> | | **[[6cg0]], [[6oem]], [[6oen]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br /> |
| | **[[8i9m]] – hHMG-1 89-183 + RAGE – Cryo EM<br /> |
| | **[[9cg9]] – hHMG-1 + nucleosome – Cryo EM<br /> |
| **[[2eqz]], [[2yqi]] – hHMG-3 box domain - NMR<br /> | | **[[2eqz]], [[2yqi]] – hHMG-3 box domain - NMR<br /> |
| **[[1j3d]] – pHMG-2 C terminal – pig - NMR<br /> | | **[[1j3d]] – pHMG-2 C terminal – pig - NMR<br /> |
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Line 42: |
| **[[1ckt]], [[4qr9]] – rHMG-1 A domain + DNA <br /> | | **[[1ckt]], [[4qr9]] – rHMG-1 A domain + DNA <br /> |
| **[[2gzk]] – rHMG-1 tandem boxes + DNA <br /> | | **[[2gzk]] – rHMG-1 tandem boxes + DNA <br /> |
| **[[5ze2]], [[5ze1]], [[5ze0]], [[5zdz]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – mouse<br /> | | **[[5zdz]], [[5ze0]], [[5ze1]], [[5ze2]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – mouse<br /> |
| **[[6oeo]], [[6oer]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br /> | | **[[6oeo]], [[6oer]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br /> |
| **[[1hsm]], [[1hsn]], [[1nhm]], [[1nhn]] – HMG-1 box domain – chinese hamster - NMR <br /> | | **[[1hsm]], [[1hsn]], [[1nhm]], [[1nhn]] – HMG-1 box domain – chinese hamster - NMR <br /> |
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Function
High mobility group protein (HMG) is a chromatin protein which organizes the DNA and regulates transcription. HMG superfamilies differ by their DNA-binding domains.
- HMGAs bind via an AT-hook domain. For details on HMGA see HMGI(Y).
- HMGBs bind via box domain[1].
- HMGNs bind via a nucleosome binding domain.
Disease
Rearrangements of the HMGA2 gene were detected in human benign lipoma tumors[2].
Relevance
Overexpression of HMGB1 is associated with cancer and is targeted for cancer therapy[3].
Structural highlights
- ↑ Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev. 2007 Dec;220:35-46. PMID:17979838 doi:https://dx.doi.org/10.1111/j.1600-065X.2007.00574.x
- ↑ Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V, Fusco A. Role of the high mobility group A proteins in human lipomas. Carcinogenesis. 2001 Oct;22(10):1583-91. PMID:11576996
- ↑ Tang D, Kang R, Zeh HJ 3rd, Lotze MT. High-mobility group box 1 and cancer. Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):131-40. doi:, 10.1016/j.bbagrm.2009.11.014. PMID:20123075 doi:https://dx.doi.org/10.1016/j.bbagrm.2009.11.014
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3D Structures of high mobility group protein (HMG)
Updated on 26-August-2025
{"openlevels":0}
- HMGA
- HMGB box 1 domain residues 1-84; tandem boxes domain residues 1-166
- 2yrq – hHMG-1 tandem boxes - human - NMR
- 2rtu – hHMG-1 box 1 - NMR
- 2ly4 – hHMG-1 box domain + cellular tumor antigen p53 - NMR
- 6cij, 6cik, 6cil, 6cim – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA
- 6cg0, 6oem, 6oen – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM
- 8i9m – hHMG-1 89-183 + RAGE – Cryo EM
- 9cg9 – hHMG-1 + nucleosome – Cryo EM
- 2eqz, 2yqi – hHMG-3 box domain - NMR
- 1j3d – pHMG-2 C terminal – pig - NMR
- 1j3c – pHMG-2 C terminal (mutant) - NMR
- 1j3x – pHMG-2 N terminal (mutant) - NMR
- 1hme, 1hmf – rHMG-1 B domain – rat - NMR
- 1aab – rHMG-1 A domain - NMR
- 1ckt, 4qr9 – rHMG-1 A domain + DNA
- 2gzk – rHMG-1 tandem boxes + DNA
- 5zdz, 5ze0, 5ze1, 5ze2 – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – mouse
- 6oeo, 6oer – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM
- 1hsm, 1hsn, 1nhm, 1nhn – HMG-1 box domain – chinese hamster - NMR
- 1hma – DmHMG-D DNA-binding domain – Drosophila melanogaster - NMR
- 1qrv – DmHMG-D DNA-binding domain + DNA
- 3nm9 – DmHMG-D DNA-binding domain (mutant) + DNA
- 8r1x – DmHMG-D DNA-binding domain + DNA - NMR
- HMG
- 2mrc – HMG residues 17-99 – Plasmodium falciparum - NMR
References
