9drc: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9drc is ~~ON HOLD~~

==Ternary substrate complex of DNA polymerase iota R71A mutant with DNA (template A) and dTTP==

~~Authors~~: ~~Frevert~~, Z., ~~Reusch~~, D., ~~Freudenthal~~, B., ~~Washington, M~~.T.

== Structural highlights ==

<table><tr><td colspan='2'>[[9drc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DRC OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9DRC FirstGlance].

~~Description~~: ~~Ternary substrate complex of~~ DNA polymerase ~~iota R71A mutant~~ with ~~DNA (~~template A) and ~~dTTP~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>

[[Category: ~~Reusch, D~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9drc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9drc OCA], [https://pdbe.org/9drc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9drc RCSB], [https://www.ebi.ac.uk/pdbsum/9drc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9drc ProSAT]</td></tr>

[[Category: Frevert, Z]]

</table>

[[Category: ~~Washington, M.T~~]]

== Function ==

[[Category: ~~Freudenthal, B~~]]

[https://www.uniprot.org/uniprot/POLI_HUMAN POLI_HUMAN] Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.<ref>PMID:11013228</ref> <ref>PMID:11251121</ref> <ref>PMID:11387224</ref> <ref>PMID:12410315</ref> <ref>PMID:14630940</ref> <ref>PMID:15199127</ref> <ref>PMID:15254543</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Freudenthal B]]

[[Category: Frevert Z]]

[[Category: Reusch D]]

[[Category: Washington MT]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9drc is ON HOLD
+==Ternary substrate complex of DNA polymerase iota R71A mutant with DNA (template A) and dTTP==
+<StructureSection load='9drc' size='340' side='right'caption='[[9drc]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-Authors: Frevert, Z., Reusch, D., Freudenthal, B., Washington, M.T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9drc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DRC FirstGlance]. <br>
-Description: Ternary substrate complex of DNA polymerase iota R71A mutant with DNA (template A) and dTTP
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
-[[Category: Reusch, D]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9drc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9drc OCA], [https://pdbe.org/9drc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9drc RCSB], [https://www.ebi.ac.uk/pdbsum/9drc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9drc ProSAT]</span></td></tr>
-[[Category: Frevert, Z]]
+</table>
-[[Category: Washington, M.T]]
+== Function ==
-[[Category: Freudenthal, B]]
+[https://www.uniprot.org/uniprot/POLI_HUMAN POLI_HUMAN] Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.<ref>PMID:11013228</ref> <ref>PMID:11251121</ref> <ref>PMID:11387224</ref> <ref>PMID:12410315</ref> <ref>PMID:14630940</ref> <ref>PMID:15199127</ref> <ref>PMID:15254543</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Freudenthal B]]
+[[Category: Frevert Z]]
+[[Category: Reusch D]]
+[[Category: Washington MT]]