1x0j: Difference between revisions
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New page: left|200px<br /> <applet load="1x0j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x0j, resolution 1.80Å" /> '''Crystal structure a... |
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== | ==Crystal structure analysis of the N-terminal bromodomain of human Brd2== | ||
<StructureSection load='1x0j' size='340' side='right'caption='[[1x0j]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1x0j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X0J FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x0j OCA], [https://pdbe.org/1x0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x0j RCSB], [https://www.ebi.ac.uk/pdbsum/1x0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x0j ProSAT], [https://www.topsan.org/Proteins/RSGI/1x0j TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x0/1x0j_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x0j ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Nakamura | [[Category: Nakamura Y]] | ||
[[Category: Padmanabhan | [[Category: Padmanabhan B]] | ||
[[Category: Shirouzu M]] | |||
[[Category: Shirouzu | [[Category: Umehara T]] | ||
[[Category: Umehara | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 07:42, 23 October 2024
Crystal structure analysis of the N-terminal bromodomain of human Brd2
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