9gvg: Difference between revisions
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==P116 from Mycoplasma pneumoniae in complex with mild growth suppressor monoclonal antibody== | |||
<StructureSection load='9gvg' size='340' side='right'caption='[[9gvg]], [[Resolution|resolution]] 5.06Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9gvg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Mycoplasma_pneumoniae_M129 Mycoplasma pneumoniae M129]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GVG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.06Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gvg OCA], [https://pdbe.org/9gvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gvg RCSB], [https://www.ebi.ac.uk/pdbsum/9gvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gvg ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Y213_MYCPN Y213_MYCPN] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Mycoplasma pneumoniae (MPN) is a bacterial pathogen that primarily causes atypical pneumonia. It cannot synthesize certain essential lipids and therefore relies on the host for their acquisition to survive. MPN has been detected in increased amounts within ruptured atherosclerotic plaques. In this work, we show that the protein P116 facilitates cholesterol acquisition from LDL, HDL and various cell types. Targeting P116's C-terminal domain with a monoclonal antibody inhibits cholesterol acquisition and bacterial growth in vitro. Phase contrast epifluorescence microscopy of human arteries reveals that this antibody blocks MPN binding to atherosclerotic lesions ex vivo. Additionally, an MPN chassis injected into hyperlipidemic female mice localizes to the liver and atherosclerotic plaques. Here, we report that P116 plays a role in extracting essential lipids from lipoproteins and host cells and regulates MPN localization to atheromatous plaques. The study highlights MPN's potential as a tool for targeting atherosclerotic lesions and fatty liver. | |||
Sources of essential lipids for Mycoplasma pneumoniae via P116 to target liver and atherosclerotic lesions.,Vizarraga D, Marcos M, Rotllan N, Martin J, Santos D, Camacho M, Soto B, Velasco-Reniu L, Guerra P, Pareja F, Collantes M, Wu W, Rodriguez-Arce I, Serrano L, Pinol J, Fita I, Escola-Gil JC Nat Commun. 2025 Dec 16;16(1):11159. doi: 10.1038/s41467-025-66129-5. PMID:41402265<ref>PMID:41402265</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 9gvg" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Mycoplasma pneumoniae M129]] | |||
[[Category: Fita I]] | |||
[[Category: Guerra P]] | |||
[[Category: Marcos Silva M]] | |||
[[Category: Martin Romero J]] | |||
[[Category: Pinyol J]] | |||
[[Category: Vizarraga D]] | |||
Latest revision as of 05:10, 24 December 2025
P116 from Mycoplasma pneumoniae in complex with mild growth suppressor monoclonal antibody
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