1x5d: Difference between revisions

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New page: left|200px<br /> <applet load="1x5d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x5d" /> '''The solution structure of the second thiore...
 
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[[Image:1x5d.gif|left|200px]]<br />
<applet load="1x5d" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1x5d" />
'''The solution structure of the second thioredoxin-like domain of human Protein disulfide-isomerase A6'''<br />


==About this Structure==
==The solution structure of the second thioredoxin-like domain of human Protein disulfide-isomerase A6==
1X5D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1X5D OCA].  
<StructureSection load='1x5d' size='340' side='right'caption='[[1x5d]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1x5d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5d OCA], [https://pdbe.org/1x5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5d RCSB], [https://www.ebi.ac.uk/pdbsum/1x5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5d ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5d TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDIA6_HUMAN PDIA6_HUMAN] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.<ref>PMID:15466936</ref> <ref>PMID:12204115</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x5d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x5d ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein disulfide-isomerase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Inoue M]]
[[Category: Inoue, M.]]
[[Category: Kigawa T]]
[[Category: Kigawa, T.]]
[[Category: Koshiba S]]
[[Category: Koshiba, S.]]
[[Category: Tochio N]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Yokoyama S]]
[[Category: Tochio, N.]]
[[Category: Yokoyama, S.]]
[[Category: erp5]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: p5]]
[[Category: pdia6]]
[[Category: redox]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: thioredoxin like domain]]
[[Category: txndc7]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:59:38 2007''
Retrieved from "https://proteopedia.org/1x5d"