1x5s: Difference between revisions
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New page: left|200px<br /> <applet load="1x5s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x5s" /> '''Solution structure of RRM domain in A18 hnR... |
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== | ==Solution structure of RRM domain in A18 hnRNP== | ||
<StructureSection load='1x5s' size='340' side='right'caption='[[1x5s]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1x5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5S FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5s OCA], [https://pdbe.org/1x5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5s RCSB], [https://www.ebi.ac.uk/pdbsum/1x5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5s ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5s TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CIRBP_HUMAN CIRBP_HUMAN] Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.<ref>PMID:11574538</ref> <ref>PMID:16513844</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x5s_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x5s ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Muto | [[Category: Muto Y]] | ||
[[Category: Sato A]] | |||
[[Category: Sato | [[Category: Shirouzu M]] | ||
[[Category: Shirouzu | [[Category: Terada T]] | ||
[[Category: Terada | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 14:01, 9 May 2024
Solution structure of RRM domain in A18 hnRNP
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