1x68: Difference between revisions

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New page: left|200px<br /> <applet load="1x68" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x68" /> '''Solution structures of the C-terminal LIM d...
 
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[[Image:1x68.gif|left|200px]]<br />
<applet load="1x68" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1x68" />
'''Solution structures of the C-terminal LIM domain of human FHL5 protein'''<br />


==Disease==
==Solution structures of the C-terminal LIM domain of human FHL5 protein==
Known diseases associated with this structure: Alpha-1-antichymotrypsin deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107280 107280]], Cerebrovascular disease, occlusive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107280 107280]]
<StructureSection load='1x68' size='340' side='right'caption='[[1x68]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1x68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X68 FirstGlance]. <br>
1X68 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1X68 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x68 OCA], [https://pdbe.org/1x68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x68 RCSB], [https://www.ebi.ac.uk/pdbsum/1x68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x68 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x68 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FHL5_HUMAN FHL5_HUMAN] May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.<ref>PMID:11327716</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/1x68_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x68 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: Nameki, N.]]
[[Category: Nameki N]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Sasagawa A]]
[[Category: Sasagawa, A.]]
[[Category: Sato M]]
[[Category: Sato, M.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: ZN]]
[[Category: an actin-interacting protein]]
[[Category: four-and-a-half lim protein 5]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: zinc finger domain]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:00:55 2007''
Retrieved from "https://proteopedia.org/1x68"