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New page: left|200px<br /> <applet load="2cdy" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cdy, resolution 2.00Å" /> '''MANGANESE SUPEROXID...
 
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[[Image:2cdy.gif|left|200px]]<br />
<applet load="2cdy" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2cdy, resolution 2.00&Aring;" />
'''MANGANESE SUPEROXIDE DISMUTASE (MN-SOD) FROM DEINOCOCCUS RADIODURANS'''<br />


==Overview==
==Manganese Superoxide Dismutase (Mn-SOD) from Deinococcus radiodurans==
The structure of the manganese superoxide dismutase (Mn-SOD; DR1279) from, Deinococcus radiodurans has been determined in two different crystal, forms. Both crystal forms are monoclinic with space group P2(1). Form I, has unit-cell parameters a = 44.28, b = 83.21, c = 59.52 angstroms, beta =, 110.18 degrees and contains a homodimer in the asymmetric unit, with, structure refinement (R = 16.8%, R(free) = 23.6%) carried out using data, to d(min) = 2.2 angstroms. Form II has unit-cell parameters a = 43.57, b =, 87.10, c = 116.42 angstroms, beta = 92.1 degrees and an asymmetric unit, containing two Mn-SOD homodimers; structure refinement was effected to a, resolution of 2.0 angstroms (R = 17.2%, R(free) = 22.3%). The resulting, structures are compared with that of Mn-SOD from Escherichia ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16582477 (full description)]]
<StructureSection load='2cdy' size='340' side='right'caption='[[2cdy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cdy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdy OCA], [https://pdbe.org/2cdy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdy RCSB], [https://www.ebi.ac.uk/pdbsum/2cdy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SODM_DEIRA SODM_DEIRA] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cdy ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the manganese superoxide dismutase (Mn-SOD; DR1279) from Deinococcus radiodurans has been determined in two different crystal forms. Both crystal forms are monoclinic with space group P2(1). Form I has unit-cell parameters a = 44.28, b = 83.21, c = 59.52 angstroms, beta = 110.18 degrees and contains a homodimer in the asymmetric unit, with structure refinement (R = 16.8%, R(free) = 23.6%) carried out using data to d(min) = 2.2 angstroms. Form II has unit-cell parameters a = 43.57, b = 87.10, c = 116.42 angstroms, beta = 92.1 degrees and an asymmetric unit containing two Mn-SOD homodimers; structure refinement was effected to a resolution of 2.0 angstroms (R = 17.2%, R(free) = 22.3%). The resulting structures are compared with that of Mn-SOD from Escherichia coli, with which they are shown to be essentially isostructural.


==About this Structure==
Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms.,Dennis RJ, Micossi E, McCarthy J, Moe E, Gordon EJ, Kozielski-Stuhrmann S, Leonard GA, McSweeney S Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):325-9. Epub 2006 Mar 25. PMID:16582477<ref>PMID:16582477</ref>
2CDY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]] with MN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CDY OCA]].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms., Dennis RJ, Micossi E, McCarthy J, Moe E, Gordon EJ, Kozielski-Stuhrmann S, Leonard GA, McSweeney S, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):325-9. Epub 2006 Mar 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16582477 16582477]
</div>
[[Category: Deinococcus radiodurans]]
<div class="pdbe-citations 2cdy" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
[[Category: Dennis, R.]]
[[Category: Gordon, E.]]
[[Category: Leonard, G.]]
[[Category: Mccarthy, J.]]
[[Category: Mcsweeney, S.]]
[[Category: Micossi, E.]]
[[Category: Moe, E.]]
[[Category: MN]]
[[Category: deinococcus radiodurans]]
[[Category: manganese superoxide dismutase]]
[[Category: oxidoreductase]]
[[Category: radiation resistance]]


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 18:37:06 2007''
==See Also==
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Deinococcus radiodurans R1]]
[[Category: Large Structures]]
[[Category: Dennis R]]
[[Category: Gordon E]]
[[Category: Leonard G]]
[[Category: McCarthy J]]
[[Category: McSweeney S]]
[[Category: Micossi E]]
[[Category: Moe E]]
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