9h6m: Difference between revisions
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==Flavin-dependent tryptophan 7-halogenase RebH in complex with 6-bromo-L-tryptophan== | |||
<StructureSection load='9h6m' size='340' side='right'caption='[[9h6m]], [[Resolution|resolution]] 2.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9h6m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lentzea_aerocolonigenes Lentzea aerocolonigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9H6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9H6M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9h6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9h6m OCA], [https://pdbe.org/9h6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9h6m RCSB], [https://www.ebi.ac.uk/pdbsum/9h6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9h6m ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TRP7H_LENAE TRP7H_LENAE] Involved in the biosynthesis of the indolocarbazole antitumor agent rebeccamycin (PubMed:11983340, PubMed:15743914). Catalyzes the chlorination of tryptophan (Trp) at C7 position to yield 7-chlorotryptophan (PubMed:15743914, PubMed:17260957). It is also able to use bromide ions to generate monobrominated Trp (PubMed:15743914).<ref>PMID:11983340</ref> <ref>PMID:15743914</ref> <ref>PMID:17260957</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Lentzea aerocolonigenes]] | |||
[[Category: Bork S]] | |||
[[Category: Niemann HH]] | |||
Latest revision as of 06:16, 25 June 2025
Flavin-dependent tryptophan 7-halogenase RebH in complex with 6-bromo-L-tryptophan
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