9k3p: Difference between revisions

Latest revision as of 05:45, 6 August 2025

Cryo-EM structure of the unliganded human melanocortin receptor 1 (MC1R)-Gs complex

Structural highlights

9k3p is a 6 chain structure with sequence from Bos taurus, Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.98Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

MSHR_HUMAN Familial melanoma;Oculocutaneous albinism type 2. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Function

MSHR_HUMAN Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:11442765, PubMed:11707265, PubMed:1325670, PubMed:1516719, PubMed:8463333). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11707265, PubMed:1325670, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585).^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7] ^[8]

References

↑ Jiménez-Cervantes C, Olivares C, González P, Morandini R, Ghanem G, García-Borrón JC. The Pro162 variant is a loss-of-function mutation of the human melanocortin 1 receptor gene. J Invest Dermatol. 2001 Jul;117(1):156-8. PMID:11442765 doi:10.1046/j.0022-202x.2001.01393.x
↑ Jiménez-Cervantes C, Germer S, González P, Sánchez J, Sánchez CO, García-Borrón JC. Thr40 and Met122 are new partial loss-of-function natural mutations of the human melanocortin 1 receptor. FEBS Lett. 2001 Nov 9;508(1):44-8. PMID:11707265 doi:10.1016/s0014-5793(01)03025-3
↑ Mountjoy KG, Robbins LS, Mortrud MT, Cone RD. The cloning of a family of genes that encode the melanocortin receptors. Science. 1992 Aug 28;257(5074):1248-51. PMID:1325670 doi:10.1126/science.1325670
↑ Chhajlani V, Wikberg JE. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett. 1992 Sep 14;309(3):417-20. PMID:1516719 doi:10.1016/0014-5793(92)80820-7
↑ Nakayama K, Soemantri A, Jin F, Dashnyam B, Ohtsuka R, Duanchang P, Isa MN, Settheetham-Ishida W, Harihara S, Ishida T. Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. Hum Genet. 2006 Apr;119(3):322-30. PMID:16463023 doi:10.1007/s00439-006-0141-1
↑ Pérez-Oliva AB, Olivares C, Jiménez-Cervantes C, García-Borrón JC. Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. J Biol Chem. 2009 Nov 13;284(46):31714-25. PMID:19737927 doi:10.1074/jbc.M109.028100
↑ Ozdeslik RN, Olinski LE, Trieu MM, Oprian DD, Oancea E. Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11508-11517. PMID:31097585 doi:10.1073/pnas.1902825116
↑ Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T. Molecular cloning of a novel melanocortin receptor. J Biol Chem. 1993 Apr 15;268(11):8246-50 PMID:8463333

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OCA

[1] Jiménez-Cervantes C, Olivares C, González P, Morandini R, Ghanem G, García-Borrón JC. The Pro162 variant is a loss-of-function mutation of the human melanocortin 1 receptor gene. J Invest Dermatol. 2001 Jul;117(1):156-8. PMID:11442765 doi:10.1046/j.0022-202x.2001.01393.x

[2] Jiménez-Cervantes C, Germer S, González P, Sánchez J, Sánchez CO, García-Borrón JC. Thr40 and Met122 are new partial loss-of-function natural mutations of the human melanocortin 1 receptor. FEBS Lett. 2001 Nov 9;508(1):44-8. PMID:11707265 doi:10.1016/s0014-5793(01)03025-3

[3] Mountjoy KG, Robbins LS, Mortrud MT, Cone RD. The cloning of a family of genes that encode the melanocortin receptors. Science. 1992 Aug 28;257(5074):1248-51. PMID:1325670 doi:10.1126/science.1325670

[4] Chhajlani V, Wikberg JE. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett. 1992 Sep 14;309(3):417-20. PMID:1516719 doi:10.1016/0014-5793(92)80820-7

[5] Nakayama K, Soemantri A, Jin F, Dashnyam B, Ohtsuka R, Duanchang P, Isa MN, Settheetham-Ishida W, Harihara S, Ishida T. Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. Hum Genet. 2006 Apr;119(3):322-30. PMID:16463023 doi:10.1007/s00439-006-0141-1

[6] Pérez-Oliva AB, Olivares C, Jiménez-Cervantes C, García-Borrón JC. Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. J Biol Chem. 2009 Nov 13;284(46):31714-25. PMID:19737927 doi:10.1074/jbc.M109.028100

[7] Ozdeslik RN, Olinski LE, Trieu MM, Oprian DD, Oancea E. Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11508-11517. PMID:31097585 doi:10.1073/pnas.1902825116

[8] Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T. Molecular cloning of a novel melanocortin receptor. J Biol Chem. 1993 Apr 15;268(11):8246-50 PMID:8463333

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9k3p is ON HOLD
+==Cryo-EM structure of the unliganded human melanocortin receptor 1 (MC1R)-Gs complex==
+<StructureSection load='9k3p' size='340' side='right'caption='[[9k3p]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
-Authors: Feng, W.B., Zhou, Q.T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9k3p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K3P FirstGlance]. <br>
-Description: Cryo-EM structure of the ligand-free human melanocortin receptor 1 (MC1R)-Gs complex
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k3p OCA], [https://pdbe.org/9k3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k3p RCSB], [https://www.ebi.ac.uk/pdbsum/9k3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k3p ProSAT]</span></td></tr>
-[[Category: Feng, W.B]]
+</table>
-[[Category: Zhou, Q.T]]
+== Disease ==
+[https://www.uniprot.org/uniprot/MSHR_HUMAN MSHR_HUMAN] Familial melanoma;Oculocutaneous albinism type 2. Disease susceptibility is associated with variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/MSHR_HUMAN MSHR_HUMAN] Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:11442765, PubMed:11707265, PubMed:1325670, PubMed:1516719, PubMed:8463333). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11707265, PubMed:1325670, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585).<ref>PMID:11442765</ref> <ref>PMID:11707265</ref> <ref>PMID:1325670</ref> <ref>PMID:1516719</ref> <ref>PMID:16463023</ref> <ref>PMID:19737927</ref> <ref>PMID:31097585</ref> <ref>PMID:8463333</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bos taurus]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Synthetic construct]]
+[[Category: Feng WB]]
+[[Category: Wang MW]]
+[[Category: Yang DH]]
+[[Category: Zheng C]]
+[[Category: Zhou QT]]

9k3p: Difference between revisions

Latest revision as of 05:45, 6 August 2025

Cryo-EM structure of the unliganded human melanocortin receptor 1 (MC1R)-Gs complex

Structural highlights

Disease

Function

References

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